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Forschungsinstitut fuer AugenheilkundeForschungsinstitut fuer AugenheilkundeForschungsinstitut fuer Augenheilkunde
Forschungsinstitut fuer Augenheilkunde
INSTITUTE FOR OPHTHALMIC RESEARCH
FORSCHUNGSINSTITUT FÜR AUGENHEILKUNDE

Karsten Boldt

Dr. rer. nat.
Senior Staff Scientist
Deputy Head of the Division of Molecular Biology of Retinal Degenerations
 

Business address

Molecular Biology of Retinal Degenerations
Institute for Ophthalmic Research
University of Tübingen
Elfriede-Aulhorn-Strasse 7
D-72076 Tübingen,
Germany

Phone: +49 (0)7071 29-84950
Fax: +49 (0)7071 29-5777
E-mail: karsten.boldt@uni-tuebingen.de

Academic Education

2009Dr. rer. nat., Protein complex analysis of disease associated proteins, Technische Universität München
2005Diploma, Biology, Eberhard-Karls Universität Tübingen

Professional Experience

01/2010-recentSenior Staff Scientist, Ciliary protein network analysis, Protein networks in cell signalling, Institute for Ophthalmic Research, Eberhard-Karls Universität Tübingen
09/2009-12/2009Postdoc, Quantitative protein complex analysis, Department of Protein Science, Helmholtz-Zentrum München
07/2005-08/2009PhD student, Protein complex analysis of disease associated proteins, Department of Protein Science, Helmholtz-Zentrum München
05/2004-05/2005Diploma student, Phospho-proteomic analysis of FPRL-1 stimulated human neutrophils, Boehringer-Ingelheim Pharma Gmbh & Co. KG

Awards

2015PRO RETINA Retinitis-Pigmentosa-Prize 2015
2011Paula and Richard von Hertwig Prize for interdisciplinary collaboration
200916. Arbeitstagung: Mikromethoden in der Proteinchemie, Martinsried, Germany:
Nachwuchspreis Proteinanalytik

Funded grants

EU-ETN

Boldt / Ueffing, EU-ETN: SCilS, European Training Network for Studying Ciliary Signalling In Development and Disease, 2019-2023, 252.788 €

ProRetina

Boldt, Dissection of the function of Lebercilin and its dys-function in Lebers Congenital Amaurosis, 2019-2020, 30.000 €

Wellcome Trust

Boldt / Ueffing, Wellcome Tust: Impact of missense mutations in recessive Mendelian disease: insight from ciliopathies, 2018-2023, 1.021.987 €

Medical faculty, fortüne

Boldt, Dissection of the function of Lebercilin and its dys-function in Lebers Congenital Amaurosis, 2017-2018, 89.000 €
European Union, FP7Ueffing / Boldt, PRIMES: Protein interaction machines in oncogenic EGF receptor, 2011-2016, 980.000 €

Memberships and Functions in Scientific Societies

  • German Society for Proteome Research

Publications

  1. Lokaj M, Kösling SK, Koerner C, Lange SM, van Beersum SE, van Reeuwijk J, Roepman R, Horn N, Ueffing M, Boldt K, Wittinghofer A. The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure. 2015 Nov 3;23(11):2122-32. doi: 10.1016/j.str.2015.08.016. Epub 2015 Oct 9. PubMed PMID: 26455799; PubMed Central PMCID: PMC4635315.
  2. Dona M, Bachmann-Gagescu R, Texier Y, Toedt G, Hetterschijt L, Tonnaer EL, Peters TA, van Beersum SE, Bergboer JG, Horn N, de Vrieze E, Slijkerman RW, van Reeuwijk J, Flik G, Keunen JE, Ueffing M, Gibson TJ, Roepman R, Boldt K, Kremer H, van Wijk E. NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish. PLoS Genet. 2015 Oct 20;11(10):e1005574. doi: 10.1371/journal.pgen.1005574. eCollection 2015 Oct. PubMed PMID: 26485514; PubMed Central PMCID: PMC4617706
  3. Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TT, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJ, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJ, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF; UK10K Consortium; University of Washington Center for Mendelian Genomics, Stewart, F, Omran H, Huynen MA, Sergouniotis PI, Alkuraya FS, Parboosingh JS, Innes AM, Willoughby CE, Giles RH, Webster AR, Ueffing M, Blacque O, Gleeson JG, Wolfrum U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA. AnsiRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol. 2015 Jul 13. doi: 10.1038/ncb3201. [Epub ahead of print] PubMed PMID: 26167768.
  4. Agca C, Boldt K, Gubler A, Meneau I, Corpet A, Samardzija M, Stucki M, Ueffing M, Grimm C. Expression of leukemia inhibitory factor in Müller glia cells is regulated by a redox-dependent mRNA stability mechanism. BMC Biology. 2015. Apr 25;13:30. doi: 10.1186/s12915-015-0137-1.
  5. Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, Scambler PJ, Ueffing M, Kayserili H, Krakow D, King SM, Beales PL, Al-Gazali L, Wicking C, Cormier-Daire V, Roepman R, Mitchison HM, Witman GB; UK10K. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications. 2015 Jun 5;6:7074. doi: 10.1038/ncomms8074.
  6. Essers PB, Klasson TD, Pereboom TC, Mans DA, Nicastro M, Boldt K, Giles RH, Macinnes AW. The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Oncogene. 2015 Feb 5;34(6):771-9. doi: 10.1038/onc.2013.598. Epub 2014 Jan 27.
  7. Texier Y, Toedt G, Gorza M, Mans DA, van Reeuwijk J, Horn N, Willer J, Katsanis N, Roepman R, Gibson TJ, Ueffing M, Boldt K. EPASIS: Elution profile analysis of SDS-induced sub-complexes by quantitative mass spectrometry. Molecular and Cellular Proteomics. 2014 May;13(5):1382-91. doi: 10.1074/mcp.O113.033233. Epub 2014 Feb 2
  8. Vogt A, Fuerholzner B, Kinkl N, Boldt K#, Ueffing M. ICPL-IP: A novel approach for quantitative protein complex analysis from native tissue. Molecular and Cellular Proteomics. 2013 May; 12(5): 1395-406. doi: 10.1074/mcp.O112 .023648. Epub 2012 Dec 26
  9. Boldt K*, Mans DA*, Won J*, van Reeuwijk J, Vogt A, Kinkl N, Letteboer SJF, Hicks WL, Hurd RE, Naggert JK, Texier Y, den Hollander AI, Koenekoop RK, Bennett J, Cremers FP, Gloeckner CJ, Nishina PM, Roepman R, Marius Ueffing#. Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. Journal of Clinical Investigation. 2011 Jun 1;121(6):2169-80. doi: 10.1172/JCI45627    
  10. Bengel D*, Boldt K*, Davis EE, Burtscher I, Trümbach D, Diplas B, Attié-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H. Pitchfork regulates cilia disassembly and left-right asymmetry. Developmental Cell. 2010 Jul 20;19(1):66-77