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Forschungsinstitut fuer AugenheilkundeForschungsinstitut fuer AugenheilkundeForschungsinstitut fuer Augenheilkunde
Forschungsinstitut fuer Augenheilkunde
INSTITUTE FOR OPHTHALMIC RESEARCH
FORSCHUNGSINSTITUT FÜR AUGENHEILKUNDE

Optic Neuritis

The Aulhorn flicker test, an analog test, previously showed high specificity and moderate sensitivity in diagnosing acute optic neuritis (ON) and provided a valuable tool for monitoring the course of the disease. We recently developed a new, digitalized version of the Aulhorn Flicker test displaying a high specificity of 0.96 and a sensitivity of 0.93. Our study indicates the digital flicker test to be an accurate and easy-to-use tool in diagnosing acute ON, which will be especially helpful in atypical cases.

Main publications regarding this topic (see also complete list)

  1. Trauzettel-Klosinski S, Aulhorn E (1987) Measurement of brightness sensation caused by flickering light. A simple and highly specific test for assessing the florid stage of optic neuritis. Clin Vis Sci 2: 63-82.
  2. Trauzettel-Klosinski S (1989) Various stages of optic neuritis assessed by subjective brightness of flicker. Arch Ophthalmol 107: 63-68. https://jamanetwork.com/journals/jamaophthalmology/article-abstract/637633
  3. Trauzettel-Klosinski S, Schüpbach M, Aulhorn E (1989) Standardization of the Tübingen Flicker Test. Graefes Arch Clin Exp Ophthalmol 227: 221-229. https://link.springer.com/content/pdf/10.1007/BF02172753.pdf
  4. Trauzettel-Klosinski S (1992) The Aulhorn Flicker test: Possibilities and limits. Its use in optic neuritis for diagnosis, differential diagnosis, monitoring the course of the disease and assessing the effect of oral prednisolone. German J Ophthalmol 1: 415- 423.
  5. Trauzettel-Klosinski S, Axmann D, Diener, HC (1993) The Tübingen study on optic neuritis treatment - a prospective, randomized and controlled trial. Clin Vis Sci 8: 385-394.
  6. Trauzettel-Klosinski S, Diener H-C, Dietz K, Zrenner E (1996) The effect of oral Prednisolone on VEP-latencies in acute optic neuritis- monitored in a prospective, randomized and controlled study. Doc Ophthalmol 91: 165-179 https://link.springer.com/content/pdf/10.1007/BF01203696.pdf
  7. Pihl-Jensen G, Ivanov IV, Hinze D, Trauzettel-Klosinski S, Frederiksen J (2019) Sensitive assessment of acute optic neuritis by a new, digital flicker test. Ophthalmic Research, DOI:  10.1159/000503304 https://www.karger.com/Article/FullText/503304