Most important publications

1. Neuroprotection

• Schnichels S, Schultheiss M, Klemm P, Blak M, Herrmann T, Melchinger M, Bartz-Schmidt KU, Löscher M, Zeck G, Spitzer MS, Hurst J. Cyclosporine A Protects Retinal Explants against Hypoxia. Int J Mol Sci. 2021 Sep 22;22(19):10196. IF: 6,208
• Mueller-Buehl AM, Tsai T, Hurst J, Theiss C, Peters L, Hofmann L, Herms F, Kuehn S, Schnichels S, Joachim SC. Reduced Retinal Degeneration in an Oxidative Stress Organ Culture Model through an iNOS-Inhibitor. Biology (Basel). 2021 Apr 28;10(5):383. IF: 5,168
• Hurst J, Mueller-Buehl AM, Hofmann L, Kuehn S, Herms F, Schnichels S, Joachim SC iNOS-inhibitor Driven Neuroprotection in a Porcine Retina Organ Culture Model J Cell Mol Med. 2020 Apr;24(7):4312-4323. Epub 2020 Mar 4. IF: 5.310
• Mueller-Buehl AM, Doepper H, Grauthoff S, Kiebler T, Peters L, Hurst J, Kuehn S, Bartz-Schmidt KU, Dick HB, Joachim SC, Schnichels S Oxidative stress-induced retinal damage is prevented by mild hypothermia in an ex vivo model of cultivated porcine retinas. Clin Exp Ophthalmol. 2020 Jul;48(5):666-681. Epub 2020 Mar 10. IF: 4,207
• Maliha AM, Kühn S, Hurst J, Herms F, Fehr M, Bartz-Schmidt KU, Dick HB, Joachim SC & Schnichels S Diminished apoptosis in hypoxic porcine retina explant cultures through hypothermia Scientific Reports 2019 Mar 20;9(1):4898. IF: 3,998
• Gaub P, Joshi Y, Wuttke A, Naumann U, Schnichels S, Heiduschka P & Di Giovanni S The histone acetyltransferase p300 promotes intrinsic axonal regeneration. Brain. 2011 Jul;134(Pt 7):2134-48. IF: 9,457

2.& 3. Drug & Gene Delivery Systems

• Schnichels S, Simmang D, Löscher M, Herrmann A, de Vries JW, Spitzer MS, Hurst J Lipid-DNA Nanoparticles as Drug-Delivery Vehicles for the Treatment of Retinal Diseases Pharmaceutics. 2023, 15(2), 532. IF: 5,4
• Löscher M, Seiz C, Hurst J, Schnichels S. Topical Drug Delivery to the Posterior Segment of the Eye. Pharmaceutics. 2022 Jan 6;14(1):134. IF: 5,4; Review
• Schnichels S, Hurst J, de Vries JW, Ullah S, Frößl K, Gruszka A, Löscher M, Bartz-Schmidt KU, Spitzer MS, Herrmann A. Improved Treatment Options for Glaucoma with Brimonidine-Loaded Lipid DNA Nanoparticles. ACS Appl Mater Interfaces. 2021 Mar 3;13(8):9445-9456. Epub 2021 Feb 2. IF: 9.229
• Schnichels S, Hurst J, de Vries JW, Ullah S, Gruszka A, Kwak M, Löscher M, Dammeier S, Bartz-Schmidt KU, Spitzer MS, Herrmann A. Self-assembled DNA nanoparticles loaded with travoprost for glaucoma-treatment. Nanomedicine. 2020 Oct;29:102260. Epub 2020 Jul 3. IF: 6,458
• Wu Z, Troll J, Jeong HH, Wei Q, Stang M, Ziemssen F, Wang Z, Dong M, Schnichels S, Qiu T & Fischer P A swarm of slippery micropropellers penetrates the vitreous body of the eye. Sci Adv. 2018 Nov 2;4(11):eaat4388. IF: 12.804
• de Vries JW, Schnichels S, Hurst J, Strudel L, Gruszka A, Kwak M, Bartz-Schmidt KU, Spitzer MS & Herrmann A DNA nanoparticles for ophthalmic drug delivery. Biomaterials. 2018 Mar;157:98-106. Epub 2017 Nov 29. IF: 10.279

4. Organ cultures and spheroids

• Fietz A, Schnichels S, Hurst J. Co-cultivation of primary porcine RPE cells and neuroretina induces inflammation: a potential inflammatory AMD-model. Scientific Reports 2023 Nov 7;13(1):19345. IF: 4.997
• Fietz A, Hurst J, Schnichels S Out of the Shadow: Blue Light Exposure Induces Apoptosis in Müller Cells. Int J Mol Sci. 2022 Nov 22;23(23):14540. IF: 5.6
• Schnichels S, Paquet-Durand F, Löscher M, Tsai T, Hurst J, Joachim SC, Klettner A. Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina. Prog Retin Eye Res. 2020 Jul 25:100880. IF: 21.198; Review
• Hurst J, Fietz A, Tsai T, Joachim SC, Schnichels S. Organ Cultures for Retinal Diseases. Front Neurosci. 2020 Nov 25;14:583392. eCollection 2020. IF: 4,677; Review.
• Kuehn S, Hurst J, Rensinghoff F, Tsai T, Grauthoff S, Satgunarajah Y, Dick HB, Schnichels S & Joachim SC. Degenerative effects of cobalt-chloride treatment on neurons and microglia in a porcine retina organ culture model. Exp Eye Res. 2017 Feb;155:107-120. Epub 2017 Jan 12. IF: 3,152
• Schnichels S, Dorfi T, Schultheiss M, Arango-Gonzalez B, Bartz-Schmidt KU, Januschowski K, Spitzer MS & Ziemssen F Ex-vivo-examination of ultrastructural changes in organotypic retina culture using near-infrared imaging and optical coherence tomography. Exp Eye Res. 2016 Jun;147:31-6. Epub 2016 Apr 21. IF: 3,332