Regine Mühlfriedel
Post-Doc, Dr. rer. nat.
Gene Therapy Section Head
Business address
Institute for Ophthalmic Research
Centre for Ophthalmology,
University of Tübingen
Elfriede-Aulhorn-Straße 7
72076 Tübingen
Germany
Phone: +49 (0)7071 29-87784
Fax: +49 (0)7071 29-4503
E-mail: regine.muehlfriedel@med.uni-tuebingen.de
Academic Education
| 2006 | Doctoral Thesis, Dr. rer. nat., Molecular Developmental Biology, Göttingen University, Germany |
| 2001 | Diploma of Biology, Molecular Genetics, Jena University, Germany |
Professional Experience
| 07/2011 | Senior Research Fellow, Exp. Ophthalmology, Institute for Ophthalmic Research Tuebingen |
| 07/2009 | Advanced Postdoctoral Research Fellow, Exp. Ophthalmology, Institute for Ophthalmic Research Tuebingen |
| 07/2006 | Postdoctoral Research Fellow, Exp. Ophthalmology, Institute for Ophthalmic Research Tuebingen |
Research Interests
- Gene therapy
- Animal model for hereditary retinal diseases
- Retinal physiology and pathophysiology
- Genotyping protocol establishment for transgenic mouse lines
Additional information
| 2002 - 2005 | Member of post graduate programme »Genetics of Development«, Göttingen University, Germany |
Membership
- Association for Research in Vision and Ophthalmology (ARVO)
Publications
- Mühlfriedel R, Michalakis S, Garcia Garrido M, Biel M and Seeliger MW (2013) Optimized technique for subretinal injections in mice. In: Methods in Molecular Biology, Vol. 935: Retinal Degeneration: Methods and Protocols (Weber BH and Langmann T, eds), pp 343, New York: Humana Press.
- Gene therapy restores vision and delays degeneration in the CNGB1-/-mouse model of retinitis pigmentosa. Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Biel M, Mühlfriedel R, Michalakis S. Human Molecular Genetics. 2012 Oct 15;21(20):4486-96. Epub 2012 Jul 16.
- Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia. Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Schmidt J, Zong X, Gollisch T, Biel M, Seeliger MW. Advances in Experimental Medicine & Biology. 2012;723:183-9. No abstract available.
- A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Mühlfriedel R, Trifunović D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW. Human Molecular Genetics. 2011 Mar 1;20(5):941-7. Epub 2010 Dec 10.
- Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Paquet-Durand F, Zong X, Gollisch T, Biel M, Seeliger MW. Molecular Therapy. 2010 Dec;18(12):2057-63. Epub 2010 Jul 13.
- In vivo assessment of retinal vascular wall dimensions. Fischer MD, Huber G, Feng Y, Tanimoto N, Mühlfriedel R, Beck SC, Tröger E, Kernstock C, Preising MN, Lorenz B, Hammes HP, Seeliger MW. Investigative Ophthalmoly & Visual Science. 2010 Oct;51(10):5254-9. Epub 2010 May 5.
- Tanimoto N, Muehlfriedel R, Fischer MD, Fahl E, Humphries P, Biel M, Seeliger MW (2009) Vision tests in the mouse: functional phenotyping with electroretinography. Frontiers in Bioscience 14:2730-2737.